In 1930, Blue toured with the "Earl Carroll Vanities". Blue left the band to establish himself as a solo comedian, portraying a bald-headed dumb-bell with a goofy expression. Producer Hal Roach featured him in his "Taxi Boys" comedy shorts, but Blue's dopey character was an acquired taste and he was soon replaced by other comedians. Later in the 1930s he worked at Paramount Pictures, notably in The Big Broadcast of 1938, and later at Metro-Goldwyn-Mayer, in films such as Easy to Wed. One of my favorite roles he had was as Gene Kelly's buddy in the 1942 MGM musical For Me And My Gal.
In 1951, Blue began concentrating on managing and appearing in nightclubs in Hollywood, California and San Francisco. He once appeared in a Reno, Nevada nightclub called the Dollhouse where he lost $25,000 to its owner, Bill Welch. Blue and Maxie Rosenbloom owned and performed in Hollywood's top nightclub in the 1940s called "Slapsie Maxie's." Again, in the 1960s he opened a nightclub in Santa Monica, California, called "Ben Blue's". It quickly became the "in" place and night after night was packed with top celebrities. Ben closed the club three years later because of health problems. Blue made the cover of TV Guide's June 11, 1954 Special Issue along with Alan Young, headlining an edition featuring that season's summer replacement shows. He also made appearances in TV shows such as The Jack Benny Program and The Milton Berle Show.
In 1964 he was indicted by a federal grand jury on six counts of tax evasion for the non-payment of more than $39,000 (approximately $325,000 today) in income taxes from the nightclub he operated, the Merry‐Go‐Round, in Santa Monica, California. The case was contested for five years, before he pled no contest to a single count of evading corporate tax. He was fined $1,000, with the payment suspended.