Lindsay Lohan first read for Regina George, but the casting team felt she was closer to what they were looking for in the actress who played Cady, and since Lohan feared the "mean girl" role would harm her reputation, she agreed to play the lead. Rachel McAdams was cast as Regina because Fey felt McAdams being "kind and polite" made her perfect for such an evil-spirited character. Amanda Seyfried also read for Regina, and the producers instead suggested her for Karen due to Seyfried's "spacey and daffy sense of humor". Both Lacey Chabert and Daniel Franzese were the last actors tested for their roles. Lizzy Caplan was at first considered too pretty for the part of Janis, for which director Mark Waters felt a "Kelly Osbourne-like actress" was necessary, but Caplan was picked for being able to portray raw emotion. Fey wrote two roles based on fellow "SNL" alumni, Amy Poehler (whom Fey thought the producers would not accept because of being too young to portray a teenager's mother) and Tim Meadows, and the cast ended up with a fourth veteran of the show, Ana Gasteyer.
In an interview about the film, Fey noted, "Adults find it funny. They are the ones who are laughing. Young people watch it like a reality show. It's much too close to their real experiences so they are not exactly guffawing." Entertainment Weekly put it on its end-of-the-decade, "best-of" list, saying, "'Fetch' may never happen, but 2004's eminently quotable movie is still one of the sharpest high school satires ever. Which is pretty grool, if you ask me!" In 2006, Entertainment Weekly also named it the twelfth best high school film of all time, explaining: "There was a time when Lindsay Lohan was best known for her acting rather than her party-hopping. Showcasing Lindsay Lohan in arguably her best role to date, this Tina Fey-scripted film also boasts a breakout turn by Rachel McAdams as evil queen bee Regina George (Gretchen, stop trying to make 'fetch' happen! It's not going to happen!). While 'Mean Girls' is technically a comedy, its depiction of girl-on-girl cattiness stings incredibly true."
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